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Target
B2 bradykinin receptor
Ligand
BDBM50067928
Substrate
n/a
Meas. Tech.
ChEMBL_40294 (CHEMBL884128)
IC50
0.52±n/a nM
Citation
 Abe, Y; Kayakiri, H; Satoh, S; Inoue, T; Sawada, Y; Inamura, N; Asano, M; Aramori, I; Hatori, C; Sawai, H; Oku, T; Tanaka, H A novel class of orally active non-peptide bradykinin B2 receptor antagonists. 4. Discovery of novel frameworks mimicking the active conformation. J Med Chem 41:4587-98 (1998) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
B2 BRADYKININ | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKR2 | BKRB2_HUMAN | Bradykinin B2 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Homo sapiens (Human)
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50067928
Synonyms:
CHEMBL544623 | N-{1-[3-(2-Methyl-quinolin-8-yloxymethyl)-2,4-bis-(2-pyridin-4-yl-vinyl)-phenyl]-1H-pyrrol-2-ylmethyl}-3-[6-(2-pyridin-4-yl-vinyl)-pyridin-3-yl]-acrylamide
Type:
Small organic molecule
Emp. Form.:
C51H41N7O2
Mol. Mass.:
783.9169
SMILES:
Cc1ccc2cccc(OCc3c(\C=C\c4ccncc4)ccc(c3\C=C\c3ccncc3)-n3cccc3CNC(=O)\C=C\c3ccc(\C=C\c4ccncc4)nc3)c2n1
Structure:
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