Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50077314
Substrate
n/a
Meas. Tech.
ChEMBL_31466 (CHEMBL647988)
IC50
13230±n/a nM
Citation
 Costantino, L; Rastelli, G; Gamberini, MC; Vinson, JA; Bose, P; Iannone, A; Staffieri, M; Antolini, L; Del Corso, A; Mura, U; Albasini, A 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem 42:1881-93 (1999) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50077314
Synonyms:
2-(3,4-Dihydroxy-benzyl)-7-hydroxy-chromen-4-one | CHEMBL56890
Type:
Small organic molecule
Emp. Form.:
C16H12O5
Mol. Mass.:
284.2635
SMILES:
Oc1ccc2c(c1)oc(Cc1ccc(O)c(O)c1)cc2=O
Structure:
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