Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50077325
Substrate
n/a
Meas. Tech.
ChEMBL_31467 (CHEMBL647989)
IC50
6520±n/a nM
Citation
Costantino, L; Rastelli, G; Gamberini, MC; Vinson, JA; Bose, P; Iannone, A; Staffieri, M; Antolini, L; Del Corso, A; Mura, U; Albasini, A 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem 42:1881-93 (1999) [PubMed] Article
More Info.:
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
Inhibitor
Name:
BDBM50077325
Synonyms:
2-(3,4-Dihydroxy-phenyl)-7-hydroxy-chromen-4-one | 2-(3,4-dihydroxyphenyl)-7-hydroxy-4H-chromen-4-one | 3',4',7-trihydroxyflavon | 7,3',4'-Trihydroxyflavone | CHEMBL301624
Type:
Small organic molecule
Emp. Form.:
C15H10O5
Mol. Mass.:
270.2369
SMILES:
Oc1ccc2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1