Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50077327
Substrate
n/a
Meas. Tech.
ChEMBL_32265 (CHEMBL645599)
IC50
85690±n/a nM
Citation
 Costantino, L; Rastelli, G; Gamberini, MC; Vinson, JA; Bose, P; Iannone, A; Staffieri, M; Antolini, L; Del Corso, A; Mura, U; Albasini, A 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem 42:1881-93 (1999) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50077327
Synonyms:
7-Hydroxy-3-(4-hydroxy-benzyl)-2-methyl-chromen-4-one | CHEMBL298650
Type:
Small organic molecule
Emp. Form.:
C17H14O4
Mol. Mass.:
282.2907
SMILES:
Cc1oc2cc(O)ccc2c(=O)c1Cc1ccc(O)cc1
Structure:
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