Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50077328
Substrate
n/a
Meas. Tech.
ChEMBL_32265 (CHEMBL645599)
IC50
22270±n/a nM
Citation
 Costantino, LRastelli, GGamberini, MCVinson, JABose, PIannone, AStaffieri, MAntolini, LDel Corso, AMura, UAlbasini, A 1-Benzopyran-4-one antioxidants as aldose reductase inhibitors. J Med Chem 42:1881-93 (1999) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
AKR1B1 | ALDR_BOVIN | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bos taurus (Cattle)
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50077328
Synonyms:
7-Hydroxy-2-naphthalen-2-ylmethyl-chromen-4-one | CHEMBL59098
Type:
Small organic molecule
Emp. Form.:
C20H14O3
Mol. Mass.:
302.3234
SMILES:
Oc1ccc2c(c1)oc(Cc1ccc3ccccc3c1)cc2=O
Structure:
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