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Target
Telomerase reverse transcriptase
Ligand
BDBM50079135
Substrate
n/a
Meas. Tech.
ChEMBL_210073 (CHEMBL813597)
IC50
17000±n/a nM
Citation
 Perry, PJ; Read, MA; Davies, RT; Gowan, SM; Reszka, AP; Wood, AA; Kelland, LR; Neidle, S 2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase. J Med Chem 42:2679-84 (1999) [PubMed]  Article 
Target
Name:
Telomerase reverse transcriptase
Synonyms:
EST2 | TCS1 | TERT | TERT_HUMAN | TRT
Type:
PROTEIN
Mol. Mass.:
127099.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1447029
Residue:
1132
Sequence:
MPRAPRCRAVRSLLRSHYREVLPLATFVRRLGPQGWRLVQRGDPAAFRALVAQCLVCVPWDARPPPAAPSFRQVSCLKELVARVLQRLCERGAKNVLAFGFALLDGARGGPPEAFTTSVRSYLPNTVTDALRGSGAWGLLLRRVGDDVLVHLLARCALFVLVAPSCAYQVCGPPLYQLGAATQARPPPHASGPRRRLGCERAWNHSVREAGVPLGLPAPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSLRPSLTGARRLVETIFLGSRPWMPGTPRRLPRLPQRYWQMRPLFLELLGNHAQCPYGVLLKTHCPLRAAVTPAAGVCAREKPQGSVAAPEEEDTDPRRLVQLLRQHSSPWQVYGFVRACLRRLVPPGLWGSRHNERRFLRNTKKFISLGKHAKLSLQELTWKMSVRDCAWLRRSPGVGCVPAAEHRLREEILAKFLHWLMSVYVVELLRSFFYVTETTFQKNRLFFYRKSVWSKLQSIGIRQHLKRVQLRELSEAEVRQHREARPALLTSRLRFIPKPDGLRPIVNMDYVVGARTFRREKRAERLTSRVKALFSVLNYERARRPGLLGASVLGLDDIHRAWRTFVLRVRAQDPPPELYFVKVDVTGAYDTIPQDRLTEVIASIIKPQNTYCVRRYAVVQKAAHGHVRKAFKSHVSTLTDLQPYMRQFVAHLQETSPLRDAVVIEQSSSLNEASSGLFDVFLRFMCHHAVRIRGKSYVQCQGIPQGSILSTLLCSLCYGDMENKLFAGIRRDGLLLRLVDDFLLVTPHLTHAKTFLRTLVRGVPEYGCVVNLRKTVVNFPVEDEALGGTAFVQMPAHGLFPWCGLLLDTRTLEVQSDYSSYARTSIRASLTFNRGFKAGRNMRRKLFGVLRLKCHSLFLDLQVNSLQTVCTNIYKILLLQAYRFHACVLQLPFHQQVWKNPTFFLRVISDTASLCYSILKAKNAGMSLGAKGAAGPLPSEAVQWLCHQAFLLKLTRHRVTYVPLLGSLRTAQTQLSRKLPGTTLTALEAAANPALPSDFKTILD
  
Inhibitor
Name:
BDBM50079135
Synonyms:
3-(4-Ethyl-piperazin-1-yl)-N-{7-[3-(4-ethyl-piperazin-1-yl)-propionylamino]-9-oxo-9H-fluoren-2-yl}-propionamide | CHEMBL90759
Type:
Small organic molecule
Emp. Form.:
C31H42N6O3
Mol. Mass.:
546.7036
SMILES:
CCN1CCN(CCC(=O)Nc2ccc3-c4ccc(NC(=O)CCN5CCN(CC)CC5)cc4C(=O)c3c2)CC1
Structure:
Search PDB for entries with ligand similarity: