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Target
5-hydroxytryptamine receptor 4
Ligand
BDBM50079303
Substrate
n/a
Meas. Tech.
ChEMBL_3259 (CHEMBL617869)
IC50
>1000±n/a nM
Citation
 Tapia, I; Alonso-Cires, L; López-Tudanca, PL; Mosquera, R; Labeaga, L; Innerárity, A; Orjales, A 2,3-Dihydro-2-oxo-1H-benzimidazole-1-carboxamides with selective affinity for the 5-HT(4) receptor: synthesis and structure-affinity and structure-activity relationships of a new series of partial agonist and antagonist derivatives. J Med Chem 42:2870-80 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 4
Synonyms:
5-HT4 | 5-hydroxytryptamine receptor 4 | 5HT4R_CAVPO | HTR4 | Serotonin 4 (5-HT4) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43735.29
Organism:
GUINEA PIG
Description:
5-HT4 HTR4 GUINEA PIG::O70528
Residue:
388
Sequence:
MDKLDANVSSKEGFGSVEKVVLLTFLSAVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWVYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHARQIQVLQRAGAPAEGRPQPADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQLWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDTVECGGQWESQCHPAASSPLVAAQPIDT
  
Inhibitor
Name:
BDBM50079303
Synonyms:
3-Isopropyl-2-oxo-2,3-dihydro-benzoimidazole-1-carboxylic acid [2-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-ethyl]-amide | CHEMBL328641
Type:
Small organic molecule
Emp. Form.:
C25H31N5O4
Mol. Mass.:
465.5447
SMILES:
CC(C)n1c2ccccc2n(C(=O)NCCN2CCN(Cc3ccc4OCOc4c3)CC2)c1=O
Structure:
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