Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50170660
Substrate
n/a
Meas. Tech.
ChEMBL_1230 (CHEMBL616182)
IC50
6460±n/a nM
Citation
 Nakazato, A; Ohta, K; Sekiguchi, Y; Okuyama, S; Chaki, S; Kawashima, Y; Hatayama, K Design, synthesis, structure-activity relationships, and biological characterization of novel arylalkoxyphenylalkylamine sigma ligands as potential antipsychotic drugs. J Med Chem 42:1076-87 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50170660
Synonyms:
CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine | N-(4-methoxy-3-phenethoxyphenethyl)-N-propylpropan-1-amine | NE-100 | [2-(4-Methoxy-3-phenethyloxy-phenyl)-ethyl]-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C23H33NO2
Mol. Mass.:
355.5136
SMILES:
CCCN(CCC)CCc1ccc(OC)c(OCCc2ccccc2)c1
Structure:
Search PDB for entries with ligand similarity: