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Target
Macrophage metalloelastase
Ligand
BDBM50089199
Substrate
n/a
Meas. Tech.
ChEMBL_106456 (CHEMBL716818)
IC50
13±n/a nM
Citation
 Apfel, C; Banner, DW; Bur, D; Dietz, M; Hirata, T; Hubschwerlen, C; Locher, H; Page, MG; Pirson, W; Rossé, G; Specklin, JL Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents. J Med Chem 43:2324-31 (2000) [PubMed]  Article 
Target
Name:
Macrophage metalloelastase
Synonyms:
HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:
Enzyme
Mol. Mass.:
54012.99
Organism:
Homo sapiens (Human)
Description:
P39900
Residue:
470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
  
Inhibitor
Name:
BDBM50089199
Synonyms:
3-(Naphthalene-2-sulfonyl)-heptanoic acid hydroxyamide | CHEMBL78001
Type:
Small organic molecule
Emp. Form.:
C17H21NO4S
Mol. Mass.:
335.418
SMILES:
CCCCC(CC(=O)NO)S(=O)(=O)c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: