Reaction Details Report a problem with these data
Target
3',5'-cyclic-AMP phosphodiesterase
Ligand
BDBM50089814
Substrate
n/a
Meas. Tech.
ChEMBL_157208 (CHEMBL768859)
IC50
1170±n/a nM
Citation
 Watanabe, N; Adachi, H; Takase, Y; Ozaki, H; Matsukura, M; Miyazaki, K; Ishibashi, K; Ishihara, H; Kodama, K; Nishino, M; Kakiki, M; Kabasawa, Y 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. J Med Chem 43:2523-9 (2000) [PubMed]  Article 
Target
Name:
3',5'-cyclic-AMP phosphodiesterase
Synonyms:
Phosphodiesterase 4A
Type:
PROTEIN
Mol. Mass.:
13615.65
Organism:
Sus scrofa
Description:
ChEMBL_155848
Residue:
118
Sequence:
PWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVDIPSPTMKDHEKQQAPRQRPSQQPPPPGPQFQPMSQITGVKKLMHSSSLNEDSSIPRFGVKTDQEELLAQEL
  
Inhibitor
Name:
BDBM50089814
Synonyms:
4-(3-Chloro-4-methoxy-benzylamino)-1-(4-hydroxy-piperidin-1-yl)-phthalazine-6-carbonitrile; hydrochloride | CHEMBL266960 | CHEMBL545712
Type:
Small organic molecule
Emp. Form.:
C22H22ClN5O2
Mol. Mass.:
423.895
SMILES:
COc1ccc(CNc2nnc(N3CCC(O)CC3)c3ccc(cc23)C#N)cc1Cl
Structure:
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