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Target
Metabotropic glutamate receptor 6
Ligand
BDBM50078596
Substrate
n/a
Meas. Tech.
ChEMBL_104311 (CHEMBL718130)
Ki
>1000000±n/a nM
Citation
 Bräuner-Osborne, H; Egebjerg, J; Nielsen, EO; Madsen, U; Krogsgaard-Larsen, P Ligands for glutamate receptors: design and therapeutic prospects. J Med Chem 43:2609-45 (2000) [PubMed]  Article 
Target
Name:
Metabotropic glutamate receptor 6
Synonyms:
GPRC1F | GRM6 | GRM6_HUMAN | MGLUR6 | Metabotropic glutamate receptor 6 | glutamate receptor, metabotropic 6 precursor | metabotropic glutamate 6
Type:
Enzyme Catalytic Domain
Mol. Mass.:
95479.26
Organism:
Homo sapiens (Human)
Description:
metabotropic glutamate 6 GRM6 HUMAN::O15303
Residue:
877
Sequence:
MARPRRAREPLLVALLPLAWLAQAGLARAAGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLMETPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERIGRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGDPHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVAAPPKGEDAEAHK
  
Inhibitor
Name:
BDBM50078596
Synonyms:
(2R,4R)-1,4-Diamino-pyrrolidine-2,4-dicarboxylic acid | 4-Amino-2,4-dicarboxy-pyrrolidin-1-yl-ammonium(1-Amino-APDC) | CHEMBL297150
Type:
Small organic molecule
Emp. Form.:
C6H11N3O4
Mol. Mass.:
189.1692
SMILES:
NN1C[C@](N)(C[C@@H]1C(O)=O)C(O)=O
Structure:
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