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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50095137
Substrate
n/a
Meas. Tech.
ChEMBL_62971 (CHEMBL677461)
Ki
1960±n/a nM
Citation
 Tamiz, AP; Bandyopadhyay, BC; Zhang, J; Flippen-Anderson, JL; Zhang, M; Wang, CZ; Johnson, KM; Tella, S; Kozikowski, AP Pharmacological and behavioral analysis of the effects of some bivalent ligand-based monoamine reuptake inhibitors. J Med Chem 44:1615-22 (2001) [PubMed]  Article 
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50095137
Synonyms:
(3S,4R)-4-(4-Chloro-phenyl)-1-methyl-piperidine-3-carboxylic acid (5-{[(3S,4R)-4-(4-chloro-phenyl)-1-methyl-piperidine-3-carbonyl]-amino}-pentyl)-amide | 3N-{5-[4-(4-chlorophenyl)-1-methyl-(3S,4R)-hexahydro-3-pyridinylcarboxamido]pentyl}-4-(4-chlorophenyl)-1-methyl-(3S,4R)-hexahydro-3-pyridinecarboxamide | CHEMBL41995
Type:
Small organic molecule
Emp. Form.:
C31H42Cl2N4O2
Mol. Mass.:
573.597
SMILES:
CN1CC[C@H]([C@@H](C1)C(=O)NCCCCCNC(=O)[C@@H]1CN(C)CC[C@H]1c1ccc(Cl)cc1)c1ccc(Cl)cc1
Structure:
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