Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50107124
Substrate
n/a
Meas. Tech.
ChEMBL_38363 (CHEMBL649021)
IC50
4000±n/a nM
Citation
 Enyedy, IJ; Ling, Y; Nacro, K; Tomita, Y; Wu, X; Cao, Y; Guo, R; Li, B; Zhu, X; Huang, Y; Long, YQ; Roller, PP; Yang, D; Wang, S Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem 44:4313-24 (2001) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50107124
Synonyms:
2,9-Dimethoxy-11,12-dihydro-dibenzo[c,g][1,2]diazocine 5,6-dioxide | CHEMBL344184
Type:
Small organic molecule
Emp. Form.:
C16H16N2O4
Mol. Mass.:
300.3092
SMILES:
COc1ccc2N([O-])[N+](=O)c3ccc(OC)cc3CCc2c1
Structure:
Search PDB for entries with ligand similarity: