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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50107127
Substrate
n/a
Meas. Tech.
ChEMBL_38359 (CHEMBL651291)
IC50
7700±n/a nM
Citation
 Enyedy, IJ; Ling, Y; Nacro, K; Tomita, Y; Wu, X; Cao, Y; Guo, R; Li, B; Zhu, X; Huang, Y; Long, YQ; Roller, PP; Yang, D; Wang, S Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem 44:4313-24 (2001) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50107127
Synonyms:
3,12-dibromo-5,10-dihydroanthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione | CHEMBL135934
Type:
Small organic molecule
Emp. Form.:
C34H14Br2O2
Mol. Mass.:
614.282
SMILES:
Brc1ccc2c3ccc4c5ccc6c7ccc(Br)cc7c(=O)c7ccc(c8ccc(c3c48)c(=O)c2c1)c5c67
Structure:
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