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Target
Apoptosis regulator Bcl-2
Ligand
BDBM50107130
Substrate
n/a
Meas. Tech.
ChEMBL_38364 (CHEMBL649022)
Ki
2400±n/a nM
Citation
 Enyedy, IJ; Ling, Y; Nacro, K; Tomita, Y; Wu, X; Cao, Y; Guo, R; Li, B; Zhu, X; Huang, Y; Long, YQ; Roller, PP; Yang, D; Wang, S Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. J Med Chem 44:4313-24 (2001) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50107130
Synonyms:
(Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid | 2-[5-(4-Bromo-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-3-methyl-butyric acid | CHEMBL335265
Type:
Small organic molecule
Emp. Form.:
C15H14BrNO3S2
Mol. Mass.:
400.311
SMILES:
CC(C)C(N1C(=S)S\C(=C/c2ccc(Br)cc2)C1=O)C(O)=O
Structure:
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