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Target
Sodium/hydrogen exchanger 1
Ligand
BDBM50058759
Substrate
n/a
Meas. Tech.
ChEMBL_141044 (CHEMBL746892)
IC50
75±n/a nM
Citation
 Fukumoto, S; Imamiya, E; Kusumoto, K; Fujiwara, S; Watanabe, T; Shiraishi, M Novel, non-acylguanidine-type Na(+)/H(+) exchanger inhibitors: synthesis and pharmacology of 5-tetrahydroquinolinylidene aminoguanidine derivatives. J Med Chem 45:3009-21 (2002) [PubMed]  Article 
Target
Name:
Sodium/hydrogen exchanger 1
Synonyms:
NHE-1 | Na(+)/H(+) exchanger 1 | Nhe1 | SL9A1_RAT | Slc9a1 | Solute carrier family 9 member 1
Type:
PROTEIN
Mol. Mass.:
91655.00
Organism:
Rattus norvegicus
Description:
ChEMBL_862370
Residue:
820
Sequence:
MMLRWSGIWGLYPPRIFPSLLVVVALVGLLPVLRSHGLQLNPTASTIRGSEPPRERSIGDVTTAPSEPLHHPDDRNLTNLYIEHGAKPVRKAFPVLDIDYLHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLIKGVGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLLYAVCLVGGEQINNIGLLDTLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHLFEEFASYEYVGISDIFLGFLSFFVVSLGGVFVGVVYGVIAAFTSRFTSHIRVIEPLFVFLYSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVSTVAGSHQWNWTFVISTLLFCLIARVLGVLVLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLGYLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLLTGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGKIPSAVSTVSMQNIHPKSAASERILPALSKDKEEEIRKILRSNLQKTRQRLRSYNRHTLVADPYEEAWNQMLLRRQKARQLEQKITNYLTVPAHKLDSPTMSRARIGSDPLAYEPKADLPVITIDPASPQSPESVDLVNEELKGKVLGLKRGPRTTPEEEEEDEDGVIMIRSKEPSSPGTDDVFTPGPSDSPGSQRIQRCLSDPGPHPEPGEGEPFIPKGQ
  
Inhibitor
Name:
BDBM50058759
Synonyms:
CHEMBL436559 | CHEMBL462831 | Cariporide | N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine (Cariporide) | N-(4-Isopropyl-3-methanesulfonyl-benzoyl)-guanidine(Cariporide) | N-(4-isopropyl-3-methanesulfonyl-benzoyl)-guanidine | N-(diaminomethylene)-4-isopropyl-3-(methylsulfonyl)benzamide
Type:
Small organic molecule
Emp. Form.:
C12H17N3O3S
Mol. Mass.:
283.347
SMILES:
CC(C)c1ccc(cc1S(C)(=O)=O)C(=O)NC(N)=N
Structure:
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