Reaction Details Report a problem with these data
Target
Mast cell carboxypeptidase A
Ligand
BDBM50121929
Substrate
n/a
Meas. Tech.
ChEMBL_45636 (CHEMBL655446)
Ki
450±n/a nM
Citation
 Patchett, AA 2002 Alfred Burger Award Address in Medicinal Chemistry. Natural products and design: interrelated approaches in drug discovery. J Med Chem 45:5609-16 (2002) [PubMed]  Article 
Target
Name:
Mast cell carboxypeptidase A
Synonyms:
CBPA3_HUMAN | CPA3 | Carboxypeptidase A3 | MC-CPA
Type:
PROTEIN
Mol. Mass.:
48684.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_45634
Residue:
417
Sequence:
MRLILPVGLIATTLAIAPVRFDREKVFRVKPQDEKQADIIKDLAKTNELDFWYPGATHHVAANMMVDFRVSEKESQAIQSALDQNKMHYEILIHDLQEEIEKQFDVKEDIPGRHSYAKYNNWEKIVAWTEKMMDKYPEMVSRIKIGSTVEDNPLYVLKIGEKNERRKAIFTDCGIHAREWVSPAFCQWFVYQATKTYGRNKIMTKLLDRMNFYILPVFNVDGYIWSWTKNRMWRKNRSKNQNSKCIGTDLNRNFNASWNSIPNTNDPCADNYRGSAPESEKETKAVTNFIRSHLNEIKVYITFHSYSQMLLFPYGYTSKLPPNHEDLAKVAKIGTDVLSTRYETRYIYGPIESTIYPISGSSLDWAYDLGIKHTFAFELRDKGKFGFLLPESRIKPTCRETMLAVKFIAKYILKHTS
  
Inhibitor
Name:
BDBM50121929
Synonyms:
(phenylmethyl)butanedioic acid | 2-benzylbutanedioic acid | 2-benzylsuccinic acid | CHEMBL151284 | alpha-benzylsuccinic acid | benzylsuccinic acid | beta-carboxybenzenebutanoic acid
Type:
Small organic molecule
Emp. Form.:
C11H12O4
Mol. Mass.:
208.2106
SMILES:
OC(=O)CC(Cc1ccccc1)C(O)=O
Structure:
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