Reaction Details
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Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Ligand
BDBM50110675
Substrate
n/a
Meas. Tech.
ChEMBL_198010 (CHEMBL799062)
IC50
120±n/a nM
Citation
McCluskey, A; Sim, AT; Sakoff, JA Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies. J Med Chem 45:1151-75 (2002) [PubMed] Article More Info.:
Target
Name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B
Synonyms:
Serine-threonine protein phosphatase 2A regulatory subunit
Type:
PROTEIN
Mol. Mass.:
49694.81
Organism:
Gallus gallus
Description:
ChEMBL_161937
Residue:
426
Sequence:
DDDVAEADIISTVEFNHCGELLATGDKGGRVVIFQQEQENKIQSHSRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQKNAAQFLLSTNDKTIKLWKISERDKRPEGYNLKEEDGRYRDPTTVTTLRVPVFRPMDLMVEASPRRIFANAHTYHINSISINSDYETYLSADDLRINLWHLEITDRSFNIVDIKPANMEELTEVITAAEFHPNSCNTFVYSSSKGTIRLCDMRASALCDRHSKLFEEPEDPSNRSFFSEIISSISDVKFSHSGRYMMTRDYLSVKIWDLNMENRPVETYQVHEYLRSKLCSLYENDCIFDKFECCWNGSDSVVMTGSYNNFFRMFDRNTKRDITLEASRENNKPRTVLKPRKVCASGKRKKDEISVDSLDFNKKILHHAWHPKENIIAVATTNNLYIFQDKMN
Inhibitor
Name:
BDBM50110675
Synonyms:
2-Methyl-4,10-dioxa-tricyclo[5.2.1.0*2,6*]decane-3,5-dione | CHEMBL17096
Type:
Small organic molecule
Emp. Form.:
C9H10O4
Mol. Mass.:
182.1733
SMILES:
C[C@@]12[C@H]3CCC(O3)[C@@H]1C(=O)OC2=O
Structure:
