Reaction Details Report a problem with these data
Target
MO15-related protein kinase Pfmrk
Ligand
BDBM50132008
Substrate
n/a
Meas. Tech.
ChEMBL_52684 (CHEMBL666139)
IC50
>44000±n/a nM
Citation
 Woodard, CL; Li, Z; Kathcart, AK; Terrell, J; Gerena, L; Lopez-Sanchez, M; Kyle, DE; Bhattacharjee, AK; Nichols, DA; Ellis, W; Prigge, ST; Geyer, JA; Waters, NC Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases. J Med Chem 46:3877-82 (2003) [PubMed]  Article 
Target
Name:
MO15-related protein kinase Pfmrk
Synonyms:
Protein kinase Pfmrk
Type:
PROTEIN
Mol. Mass.:
37992.30
Organism:
Plasmodium falciparum
Description:
ChEMBL_640752
Residue:
324
Sequence:
MENNSTERYIFKPNFLGEGSYGKVYKAYDTILKKEVAIKKMKLNEISNYIDDCGINFVLLREIKIMKEIKHKNIMSALDLYCEKDYINLVMEIMDYDLSKIINRKIFLTDSQKKCILLQILNGLNVLHKYYFMHRDLSPANIFINKKGEVKLADFGLCTKYGYDMYSDKLFRDKYKKNLNLTSKVVTLWYRAPELLLGSNKYNSSIDMWSFGCIFAELLLQKALFPGENEIDQLGKIFFLLGTPNENNWPEALCLPLYTEFTKATKKDFKTYFKIDDDDCIDLLTSFLKLNAHERISAEDAMKHRYFFNDPLPCDISQLPFNDL
  
Inhibitor
Name:
BDBM50132008
Synonyms:
3-(3,3-Dimethyl-2-oxo-butylidene)-1,3-dihydro-indol-2-one | CHEMBL127506
Type:
Small organic molecule
Emp. Form.:
C14H15NO2
Mol. Mass.:
229.2744
SMILES:
CC(C)(C)C(=O)\C=C1\C(=O)Nc2ccccc12
Structure:
Search PDB for entries with ligand similarity: