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Target
Sodium-dependent serotonin transporter
Ligand
BDBM22417
Substrate
n/a
Meas. Tech.
ChEMBL_201509 (CHEMBL805636)
IC50
>500±n/a nM
Citation
 Orjales, A; Mosquera, R; Toledo, A; Pumar, MC; García, N; Cortizo, L; Labeaga, L; Innerárity, A Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters. J Med Chem 46:5512-32 (2003) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor
Type:
Multi-pass membrane protein
Mol. Mass.:
70168.43
Organism:
Rattus norvegicus (rat)
Description:
P31652
Residue:
630
Sequence:
METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEASHSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIHQSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGATLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLTLTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLISTPGTLKERIIKSITPETPTEIPCGDIRMNAV
  
Inhibitor
Name:
BDBM22417
Synonyms:
3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine | CHEMBL295467 | LY 135252 | LY 94939 | LY135252 | LY139602 | Nisoxetine | Nisoxetine Inhibitor | US9944618, Compound ID No. 177 | [3-(2-methoxyphenoxy)-3-phenylpropyl](methyl)amine | [3H]Nisoxetine
Type:
radiolabeled ligand
Emp. Form.:
C17H21NO2
Mol. Mass.:
271.3541
SMILES:
CNCCC(Oc1ccccc1OC)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: