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Target
Cyclin-dependent kinase 2
Ligand
BDBM50145922
Substrate
n/a
Meas. Tech.
ChEMBL_50506 (CHEMBL661123)
IC50
4.6±n/a nM
Citation
 Tominaga, Y; Jorgensen, WL General model for estimation of the inhibition of protein kinases using Monte Carlo simulations. J Med Chem 47:2534-49 (2004) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50145922
Synonyms:
4-[N'-(4-Iodo-2-oxo-1,2-dihydro-indol-3-ylidene)-hydrazino]-benzenesulfonamide | 4-{N'-[4-Iodo-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazino}-benzenesulfonamide | CHEMBL314397
Type:
Small organic molecule
Emp. Form.:
C14H11IN4O3S
Mol. Mass.:
442.232
SMILES:
NS(=O)(=O)c1ccc(cc1)N=Nc1c(O)[nH]c2cccc(I)c12 |w:10.10|
Structure:
Search PDB for entries with ligand similarity: