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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50140116
Substrate
n/a
Meas. Tech.
ChEMBL_71599 (CHEMBL689131)
Ki
1200±n/a nM
Citation
 Guo, Z; Zhu, YF; Gross, TD; Tucci, FC; Gao, Y; Moorjani, M; Connors, PJ; Rowbottom, MW; Chen, Y; Struthers, RS; Xie, Q; Saunders, J; Reinhart, G; Chen, TK; Bonneville, AL; Chen, C Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists. J Med Chem 47:1259-71 (2004) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50140116
Synonyms:
1-(2,6-Difluoro-benzyl)-5-(3-fluoro-phenyl)-6-methyl-3-{2-[methyl-(2-pyridin-2-yl-ethyl)-amino]-ethyl}-1H-pyrimidine-2,4-dione | CHEMBL421858
Type:
Small organic molecule
Emp. Form.:
C28H27F3N4O2
Mol. Mass.:
508.5348
SMILES:
CN(CCc1ccccn1)CCn1c(=O)c(c(C)n(Cc2c(F)cccc2F)c1=O)-c1cccc(F)c1
Structure:
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