Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Interleukin-2 receptor subunit alpha
Ligand
BDBM50370390
Substrate
n/a
Meas. Tech.
ChEMBL_89085 (CHEMBL698595)
IC50
26000±n/a nM
Citation
Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem 47:3111-30 (2004) [PubMed] Article More Info.:
Target
Name:
Interleukin-2 receptor subunit alpha
Synonyms:
CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55
Type:
PROTEIN
Mol. Mass.:
30733.96
Organism:
Mus musculus
Description:
ChEMBL_89085
Residue:
268
Sequence:
MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKELVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGHCREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTCVDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVASCLFLLISILLLSGLTWQHRWRKSRRTI
Inhibitor
Name:
BDBM50370390
Synonyms:
CHEMBL1790808
Type:
Small organic molecule
Emp. Form.:
C27H33N5O4
Mol. Mass.:
491.582
SMILES:
[#6]-[#6]-[#6@@H](-[#6])-[#6@H](\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6@@H](-[#6]-c1ccc(cc1)C#Cc1ccccc1)-[#6](=O)-[#8]-[#6]
Structure:
