Reaction Details Report a problem with these data
Target
Interleukin-2 receptor subunit alpha
Ligand
BDBM50148007
Substrate
n/a
Meas. Tech.
ChEMBL_89083 (CHEMBL698594)
IC50
2200000±n/a nM
Citation
 Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem 47:3111-30 (2004) [PubMed]  Article 
Target
Name:
Interleukin-2 receptor subunit alpha
Synonyms:
CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55
Type:
PROTEIN
Mol. Mass.:
30733.96
Organism:
Mus musculus
Description:
ChEMBL_89085
Residue:
268
Sequence:
MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKELVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGHCREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTCVDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVASCLFLLISILLLSGLTWQHRWRKSRRTI
  
Inhibitor
Name:
BDBM50148007
Synonyms:
(S)-2-(2-Methoxy-acetylamino)-3-(4-phenylethynyl-phenyl)-propionic acid | CHEMBL105741
Type:
Small organic molecule
Emp. Form.:
C20H19NO4
Mol. Mass.:
337.3692
SMILES:
COCC(=O)N[C@@H](Cc1ccc(cc1)C#Cc1ccccc1)C(O)=O
Structure:
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