Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50155550
Substrate
n/a
Meas. Tech.
ChEMBL_302867 (CHEMBL828782)
Ki
12±n/a nM
Citation
 Chazalette, C; Masereel, B; Rolin, S; Thiry, A; Scozzafava, A; Innocenti, A; Supuran, CT Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties. Bioorg Med Chem Lett 14:5781-6 (2004) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50155550
Synonyms:
2,3,5,6-Tetrafluoro-N-(5-sulfamoyl-indan-2-yl)-benzamide | 2,3,5,6-tetrafluoro-N-(5-sulfamoyl-2,3-dihydro-1H-inden-2-yl)benzamide | CHEMBL186963
Type:
Small organic molecule
Emp. Form.:
C16H12F4N2O3S
Mol. Mass.:
388.337
SMILES:
NS(=O)(=O)c1ccc2CC(Cc2c1)NC(=O)c1c(F)c(F)cc(F)c1F
Structure:
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