Reaction Details Report a problem with these data
Target
Equilibrative nucleoside transporter 1
Ligand
BDBM50159130
Substrate
n/a
Meas. Tech.
ChEMBL_303651 (CHEMBL828999)
Ki
29±n/a nM
Citation
 Tromp, RA; Spanjersberg, RF; von Frijtag Drabbe Künzel, JK; IJzerman, AP Inhibition of nucleoside transport proteins by C8-alkylamine-substituted purines. J Med Chem 48:321-9 (2005) [PubMed]  Article 
Target
Name:
Equilibrative nucleoside transporter 1
Synonyms:
ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1
Type:
Multi-pass membrane protein
Mol. Mass.:
50225.92
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
456
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
  
Inhibitor
Name:
BDBM50159130
Synonyms:
CHEMBL369726 | [9-Benzyl-6-(4-nitro-benzylsulfanyl)-9H-purin-8-yl]-cyclopentyl-amine
Type:
Small organic molecule
Emp. Form.:
C24H24N6O2S
Mol. Mass.:
460.551
SMILES:
[O-][N+](=O)c1ccc(CSc2ncnc3n(Cc4ccccc4)c(NC4CCCC4)nc23)cc1
Structure:
Search PDB for entries with ligand similarity: