Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM50128913
Substrate
n/a
Meas. Tech.
ChEBML_305455
IC50
25000±n/a nM
Citation
 Lambert, DM; Fowler, CJ The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem 48:5059-87 (2005) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50128913
Synonyms:
(5Z,8Z,11Z)-Icosa-5,8,11,14-tetraenoic acid 2-hydroxy-ethyl ester | (5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid 2-hydroxy-ethyl ester | CHEMBL58624
Type:
Small organic molecule
Emp. Form.:
C22H36O3
Mol. Mass.:
348.5194
SMILES:
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OCCO
Structure:
Search PDB for entries with ligand similarity: