Reaction Details Report a problem with these data
Target
D(4) dopamine receptor
Ligand
BDBM50172511
Substrate
n/a
Meas. Tech.
ChEMBL_320968 (CHEMBL885375)
Ki
14000±n/a nM
Citation
 Elsner, J; Boeckler, F; Heinemann, FW; Hübner, H; Gmeiner, P Pharmacophore-guided drug discovery investigations leading to bioactive 5-aminotetrahydropyrazolopyridines. Implications for the binding mode of heterocyclic dopamine D3 receptor agonists. J Med Chem 48:5771-9 (2005) [PubMed]  Article 
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50172511
Synonyms:
5-Dipropylamino-4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridine-3-carbaldehyde | CHEMBL198174
Type:
Small organic molecule
Emp. Form.:
C14H23N3O
Mol. Mass.:
249.3519
SMILES:
CCCN(CCC)C1CCn2ncc(C=O)c2C1
Structure:
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