Target
C-C chemokine receptor type 1
Ligand
BDBM50174719
Substrate
n/a
Meas. Tech.
ChEMBL_325887 (CHEMBL863244)
IC50
1700±n/a nM
Citation
 Revesz, LBollbuck, BBuhl, TEder, JEsser, RFeifel, RHeng, RHiestand, PJachez-Demange, BLoetscher, PSparrer, HSchlapbach, AWaelchli, R Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis. Bioorg Med Chem Lett 15:5160-4 (2005) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 1
Synonyms:
C-C CKR-1 | C-C chemokine receptor type 1 (CCR1) | CC-CKR-1 | CCR-1 | CCR1 | CCR1_HUMAN | CD_antigen=CD191 | CMKBR1 | CMKR1 | HM145 | LD78 receptor | MIP-1alpha-R | Macrophage inflammatory protein 1-alpha receptor | RANTES-R | SCYAR1
Type:
Enzyme
Mol. Mass.:
41180.69
Organism:
Homo sapiens (Human)
Description:
P32246
Residue:
355
Sequence:
METPNTTEDYDTTTEFDYGDATPCQKVNERAFGAQLLPPLYSLVFVIGLVGNILVVLVLVQYKRLKNMTSIYLLNLAISDLLFLFTLPFWIDYKLKDDWVFGDAMCKILSGFYYTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIIIWALAILASMPGLYFSKTQWEFTHHTCSLHFPHESLREWKLFQALKLNLFGLVLPLLVMIICYTGIIKILLRRPNEKKSKAVRLIFVIMIIFFLFWTPYNLTILISVFQDFLFTHECEQSRHLDLAVQVTEVIAYTHCCVNPVIYAFVGERFRKYLRQLFHRRVAVHLVKWLPFLSVDRLERVSSTSPSTGEHELSAGF
  
Inhibitor
Name:
BDBM50174719
Synonyms:
CHEMBL196908 | N-(2-(3-((1R,4R)-5-(4-fluorobenzyl)-2,5-diaza-bicyclo[2.2.1]heptan-2-yl)-3-oxoprop-1-enyl)-5-chlorophenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C23H23ClFN3O2
Mol. Mass.:
427.899
SMILES:
CC(=O)Nc1cc(Cl)ccc1\C=C\C(=O)N1C[C@H]2C[C@@H]1CN2Cc1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: