Reaction Details Report a problem with these data
Target
Glutamate receptor ionotropic, kainate 3
Ligand
BDBM50178148
Substrate
n/a
Meas. Tech.
ChEMBL_326526 (CHEMBL862731)
Ki
374000±n/a nM
Citation
 Dolman, NP; Troop, HM; More, JC; Alt, A; Knauss, JL; Nistico, R; Jack, S; Morley, RM; Bortolotto, ZA; Roberts, PJ; Bleakman, D; Collingridge, GL; Jane, DE Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem 48:7867-81 (2005) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, kainate 3
Synonyms:
EAA5 | Excitatory amino acid receptor 5 | GLUR7 | GRIK3 | GRIK3_HUMAN | GluR-7 | Glutamate receptor 7 | Glutamate receptor ionotropic kainate | Glutamate receptor ionotropic kainate 3 | Glutamate receptor, ionotropic kainate 3 | Glutamate-Kainate 7
Type:
Enzyme Catalytic Domain
Mol. Mass.:
104046.44
Organism:
Homo sapiens (Human)
Description:
Glutamate-Kainate 7 0 HUMAN::Q13003
Residue:
919
Sequence:
MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMACSTSLAPVFP
  
Inhibitor
Name:
BDBM50178148
Synonyms:
(RS)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione | CHEMBL372631
Type:
Small organic molecule
Emp. Form.:
C15H15N3O6
Mol. Mass.:
333.2961
SMILES:
NC(Cn1ccc(=O)n(Cc2ccccc2C(O)=O)c1=O)C(O)=O
Structure:
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