Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50176720
Substrate
n/a
Meas. Tech.
ChEMBL_327856 (CHEMBL863986)
Ki
50±n/a nM
Citation
 Starck, JP; Talaga, P; Quéré, L; Collart, P; Christophe, B; Lo Brutto, P; Jadot, S; Chimmanamada, D; Zanda, M; Wagner, A; Mioskowski, C; Massingham, R; Guyaux, M Potent anti-muscarinic activity in a novel series of quinuclidine derivatives. Bioorg Med Chem Lett 16:373-7 (2005) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_HUMAN | CHRM2 | Cholinergic, muscarinic M2 | Muscarinic acetylcholine receptor M2 and M4 | Muscarinic acetylcholine receptor M2 and M5 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:
GPCR
Mol. Mass.:
51730.61
Organism:
Homo sapiens (Human)
Description:
P08172
Residue:
466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50176720
Synonyms:
(S)-3-((R)-3-methoxyquinuclidin-3-yl)-1-phenyl-1-(pyridin-3-yl)prop-2-yn-1-ol | CHEMBL372566
Type:
Small organic molecule
Emp. Form.:
C22H24N2O2
Mol. Mass.:
348.4382
SMILES:
CO[C@@]1(CN2CCC1CC2)C#C[C@](O)(c1ccccc1)c1cccnc1 |wU:12.13,2.1,wD:12.14,2.11,THB:1:2:5.6:9.8,(-3.21,-15.79,;-1.68,-15.76,;-.87,-17.08,;-.31,-18.35,;.98,-17.3,;2.47,-17.53,;1.82,-16.27,;.36,-16.06,;-.02,-14.47,;.71,-15.41,;-2.21,-17.87,;-3.53,-18.65,;-4.86,-19.44,;-5.64,-18.12,;-6.18,-20.23,;-7.53,-19.48,;-8.85,-20.26,;-8.83,-21.81,;-7.48,-22.56,;-6.16,-21.77,;-4.07,-20.76,;-2.54,-20.74,;-1.76,-22.07,;-2.51,-23.4,;-4.05,-23.42,;-4.84,-22.11,)|
Structure:
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