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Target
Sodium-dependent noradrenaline transporter
Ligand
BDBM50180525
Substrate
n/a
Meas. Tech.
ChEMBL_344145 (CHEMBL868869)
Ki
30±n/a nM
Citation
 Cases-Thomas, MJ; Masters, JJ; Walter, MW; Campbell, G; Haughton, L; Gallagher, PT; Dobson, DR; Mancuso, V; Bonnier, B; Giard, T; Defrance, T; Vanmarsenille, M; Ledgard, A; White, C; Ouwerkerk-Mahadevan, S; Brunelle, FJ; Dezutter, NA; Herbots, CA; Lienard, JY; Findlay, J; Hayhurst, L; Boot, J; Thompson, LK; Hemrick-Luecke, S Discovery of novel and selective tertiary alcohol containing inhibitors of the norepinephrine transporter. Bioorg Med Chem Lett 16:2022-5 (2006) [PubMed]  Article 
Target
Name:
Sodium-dependent noradrenaline transporter
Synonyms:
Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:
Multi-pass membrane protein
Mol. Mass.:
69337.72
Organism:
Homo sapiens (Human)
Description:
P23975
Residue:
617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHLVAQRDIRQFQLQHWLAI
  
Inhibitor
Name:
BDBM50180525
Synonyms:
(R)-2-(2-chlorophenyl)-1-((S)-morpholin-2-yl)-1-phenylethanol | CHEMBL207713
Type:
Small organic molecule
Emp. Form.:
C18H20ClNO2
Mol. Mass.:
317.81
SMILES:
O[C@@](Cc1ccccc1Cl)([C@@H]1CNCCO1)c1ccccc1
Structure:
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