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Target
Cyclin-dependent kinase 4
Ligand
BDBM50192081
Substrate
n/a
Meas. Tech.
ChEMBL_404507 (CHEMBL910890)
IC50
170±n/a nM
Citation
 Kawanishi, N; Sugimoto, T; Shibata, J; Nakamura, K; Masutani, K; Ikuta, M; Hirai, H Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure. Bioorg Med Chem Lett 16:5122-6 (2006) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50192081
Synonyms:
3-(2-cyclopentyl-1-oxo-2,3-dihydro-1H-isoindol-4-yl)-1H-quinoxalin-2-one | CHEMBL385070
Type:
Small organic molecule
Emp. Form.:
C21H19N3O2
Mol. Mass.:
345.3945
SMILES:
O=C1N(Cc2c1cccc2-c1nc2ccccc2[nH]c1=O)C1CCCC1
Structure:
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