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Target
RNA-directed RNA polymerase
Ligand
BDBM50370763
Substrate
n/a
Meas. Tech.
ChEMBL_411597 (CHEMBL907248)
IC50
9±n/a nM
Citation
 Ikegashira, K; Oka, T; Hirashima, S; Noji, S; Yamanaka, H; Hara, Y; Adachi, T; Tsuruha, J; Doi, S; Hase, Y; Noguchi, T; Ando, I; Ogura, N; Ikeda, S; Hashimoto, H Discovery of conformationally constrained tetracyclic compounds as potent hepatitis C virus NS5B RNA polymerase inhibitors. J Med Chem 49:6950-3 (2006) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50370763
Synonyms:
CHEMBL1203926
Type:
Small organic molecule
Emp. Form.:
C30H37N3O2
Mol. Mass.:
471.6337
SMILES:
OC(=O)c1ccc2c(C3CCCCC3)c3-c4ccccc4N(CCN4CCCCC4)CCn3c2c1
Structure:
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