Reaction Details Report a problem with these data
Target
Neuromedin-K receptor
Ligand
BDBM50194594
Substrate
n/a
Meas. Tech.
ChEMBL_424448 (CHEMBL912491)
IC50
430±n/a nM
Citation
 Elliott, JM; Carling, RW; Chambers, M; Chicchi, GG; Hutson, PH; Jones, AB; MacLeod, A; Marwood, R; Meneses-Lorente, G; Mezzogori, E; Murray, F; Rigby, M; Royo, I; Russell, MG; Sohal, B; Tsao, KL; Williams, B N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists. Bioorg Med Chem Lett 16:5748-51 (2006) [PubMed]  Article 
Target
Name:
Neuromedin-K receptor
Synonyms:
NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3)
Type:
Enzyme
Mol. Mass.:
52221.96
Organism:
Homo sapiens (Human)
Description:
P29371
Residue:
465
Sequence:
MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGLPVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEGPKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADTTRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
  
Inhibitor
Name:
BDBM50194594
Synonyms:
CHEMBL218422 | N'-(8-bromo-3-methoxy-2-phenyl-quinoline-4-carbonyl)-N-phenyl-hydrazinecarboxylic acid methyl ester
Type:
Small organic molecule
Emp. Form.:
C25H20BrN3O4
Mol. Mass.:
506.348
SMILES:
COC(=O)N(NC(=O)c1c(OC)c(nc2c(Br)cccc12)-c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: