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Target
Thymidylate kinase
Ligand
BDBM50131909
Substrate
n/a
Meas. Tech.
ChEMBL_429555 (CHEMBL919553)
Ki
220000±n/a nM
Citation
 Vanheusden, V; Munier-Lehmann, H; Froeyen, M; Busson, R; Rozenski, J; Herdewijn, P; Van Calenbergh, S Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem 47:6187-94 (2004) [PubMed]  Article 
Target
Name:
Thymidylate kinase
Synonyms:
CDC8 | DTYMK | KTHY_HUMAN | TMPK | TYMK
Type:
PROTEIN
Mol. Mass.:
23824.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_946051
Residue:
212
Sequence:
MAARRGALIVLEGVDRAGKSTQSRKLVEALCAAGHRAELLRFPERSTEIGKLLSSYLQKKSDVEDHSVHLLFSANRWEQVPLIKEKLSQGVTLVVDRYAFSGVAFTGAKENFSLDWCKQPDVGLPKPDLVLFLQLQLADAAKRGAFGHERYENGAFQERALRCFHQLMKDTTLNWKMVDASKSIEAVHEDIRVLSEDAIRTATEKPLGELWK
  
Inhibitor
Name:
BDBM50131909
Synonyms:
1-((2R,4R,5S)-4-aminomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | 1-(4-Aminomethyl-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione | CHEMBL341264
Type:
Small organic molecule
Emp. Form.:
C11H17N3O4
Mol. Mass.:
255.2704
SMILES:
Cc1cn([C@H]2C[C@H](CN)[C@@H](CO)O2)c(=O)[nH]c1=O
Structure:
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