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Target
Delta-type opioid receptor
Ligand
BDBM50157801
Substrate
n/a
Meas. Tech.
ChEMBL_430155 (CHEMBL919064)
Ki
3.4±n/a nM
Citation
 Srivastava, SK; Shefali, S; Miller, CN; Aceto, MD; Traynor, JR; Lewis, JW; Husbands, SM Effects of substitution on the pyrrole N atom in derivatives of tetrahydronaltrindole, tetrahydrooxymorphindole, and a related 4,5-epoxyphenylpyrrolomorphinan. J Med Chem 47:6645-8 (2004) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50157801
Synonyms:
(1S,2S,9R)-18-(cyclopropylmethyl)-7-methyl-5-phenyl-10-oxa-7,18-diazahexacyclo[9.9.1.0^{1,9}.0^{2,17}.0^{4,8}.0^{15,21}]henicosa-4(8),5,11,13,15(21)-pentaene-2,12-diol | CHEMBL221419
Type:
Small organic molecule
Emp. Form.:
C29H30N2O3
Mol. Mass.:
454.5601
SMILES:
Cn1cc(c2C[C@@]3(O)C4Cc5ccc(O)c6O[C@@H](c12)[C@]3(CCN4CC1CC1)c56)-c1ccccc1 |r,THB:11:10:6:20.21.22,15:27:6:20.21.22|
Structure:
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