Reaction Details
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Potassium voltage-gated channel subfamily B member 1
Ligand
BDBM50213094
Substrate
n/a
Meas. Tech.
ChEMBL_436811 (CHEMBL905113)
IC50
2400±n/a nM
Citation
Plouvier, B; Beatch, GN; Jung, GL; Zolotoy, A; Sheng, T; Clohs, L; Barrett, TD; Fedida, D; Wang, WQ; Zhu, JJ; Liu, Y; Abraham, S; Lynn, L; Dong, Y; Wall, RA; Walker, MJ Synthesis and biological studies of novel 2-aminoalkylethers as potential antiarrhythmic agents for the conversion of atrial fibrillation. J Med Chem 50:2818-41 (2007) [PubMed] Article More Info.:
Target
Name:
Potassium voltage-gated channel subfamily B member 1
Synonyms:
DRK1 | Delayed rectifier potassium channel 1 | KCNB1_RAT | Kcnb1 | Voltage-gated potassium channel subunit Kv2.1
Type:
PROTEIN
Mol. Mass.:
95652.47
Organism:
Rattus norvegicus
Description:
ChEMBL_436811
Residue:
857
Sequence:
MPAGMTKHGSRSTSSLPPEPMEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLQVCDDYSLEDNEYFFDRHPGAFTSILNFYRTGRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQKKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDLLEKPNSSVAAKILAIISIMFIVLSTIALSLNTLPELQSLDEFGQSTDNPQLAHVEAVCIAWFTMEYLLRFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDDTKFKSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNMKDAFARSIEMMDIVVEKNGESIAKKDKVQDNHLSPNKWKWTKRALSETSSSKSFETKEQGSPEKARSSSSPQHLNVQQLEDMYSKMAKTQSQPILNTKEMAPQSKPPEELEMSSMPSPVAPLPARTEGVIDMRSMSSIDSFISCATDFPEATRFSHSPLASLSSKAGSSTAPEVGWRGALGASGGRLTETNPIPETSRSGFFVESPRSSMKTNNPLKLRALKVNFVEGDPTPLLPSLGLYHDPLRNRGGAAAAVAGLECASLLDKPVLSPESSIYTTASARTPPRSPEKHTAIAFNFEAGVHHYIDTDTDDEGQLLYSVDSSPPKSLHGSTSPKFSTGARTEKNHFESSPLPTSPKFLRPNCVYSSEGLTGKGPGAQEKCKLENHTPPDVHMLPGGGAHGSTRDQSI
Inhibitor
Name:
BDBM50213094
Synonyms:
(1R,2R)-1-(3,4-dichlorophenethoxy)-2-(4-morpholinyl)cyclohexane | CHEMBL387935
Type:
Small organic molecule
Emp. Form.:
C18H25Cl2NO2
Mol. Mass.:
358.303
SMILES:
Clc1ccc(CCO[C@@H]2CCCC[C@H]2N2CCOCC2)cc1Cl
Structure:
