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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50214382
Substrate
n/a
Meas. Tech.
ChEMBL_437030 (CHEMBL906424)
IC50
17000±n/a nM
Citation
 Kato, A; Kato, N; Adachi, I; Hollinshead, J; Fleet, GW; Kuriyama, C; Ikeda, K; Asano, N; Nash, RJ Isolation of glycosidase-inhibiting hyacinthacines and related alkaloids from Scilla socialis. J Nat Prod 70:993-7 (2007) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase I | Alpha-L-fucoside fucohydrolase | FUCA1 | FUCO_HUMAN | Tissue alpha-L-fucosidase
Type:
PROTEIN
Mol. Mass.:
53690.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_34088
Residue:
466
Sequence:
MRAPGMRSRPAGPALLLLLLFLGAAESVRRAQPPRRYTPDWPSLDSRPLPAWFDEAKFGVFIHWGVFSVPAWGSEWFWWHWQGEGRPQYQRFMRDNYPPGFSYADFGPQFTARFFHPEEWADLFQAAGAKYVVLTTKHHEGFTNWPSPVSWNWNSKDVGPHRDLVGELGTALRKRNIRYGLYHSLLEWFHPLYLLDKKNGFKTQHFVSAKTMPELYDLVNSYKPDLIWSDGEWECPDTYWNSTNFLSWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCEDKFKPQSLPDHKWEMCTSIDKFSWGYRRDMALSDVTEESEIISELVQTVSLGGNYLLNIGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQWEKNTTSVWYTSKGSAVYAIFLHWPENGVLNLESPITTSTTKITMLGIQGDLKWSTDPDKGLFISLPQLPPSAVPAEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50214382
Synonyms:
CHEMBL226576 | [(1S*,2R*,3R*,5R*,7S*,7a*R)-3,5-dihydroxymethyl-1,2,7-trihydroxypyrrolizidine]
Type:
Small organic molecule
Emp. Form.:
C9H17NO5
Mol. Mass.:
219.235
SMILES:
OC[C@@H]1C[C@H](O)[C@@H]2[C@H](O)[C@H](O)[C@@H](CO)N12
Structure:
Search PDB for entries with ligand similarity: