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Target
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Ligand
BDBM50214004
Substrate
n/a
Meas. Tech.
ChEMBL_438956 (CHEMBL889299)
IC50
540±n/a nM
Citation
 Pietranico, SL; Foley, LH; Huby, N; Yun, W; Dunten, P; Vermeulen, J; Wang, P; Toth, K; Ramsey, G; Gubler, ML; Wertheimer, SJ C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase. Bioorg Med Chem Lett 17:3835-9 (2007) [PubMed]  Article 
Target
Name:
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Synonyms:
PCK1 | PCKGC_HUMAN | PEPCK1 | Phosphoenolpyruvate carboxykinase cytosolic
Type:
PROTEIN
Mol. Mass.:
69189.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_438956
Residue:
622
Sequence:
MPPQLQNGLNLSAKVVQGSLDSLPQAVREFLENNAELCQPDHIHICDGSEEENGRLLGQMEEEGILRRLKKYDNCWLALTDPRDVARIESKTVIVTQEQRDTVPIPKTGLSQLGRWMSEEDFEKAFNARFPGCMKGRTMYVIPFSMGPLGSPLSKIGIELTDSPYVVASMRIMTRMGTPVLEAVGDGEFVKCLHSVGCPLPLQKPLVNNWPCNPELTLIAHLPDRREIISFGSGYGGNSLLGKKCFALRMASRLAKEEGWLAEHMLILGITNPEGEKKYLAAAFPSACGKTNLAMMNPSLPGWKVECVGDDIAWMKFDAQGHLRAINPENGFFGVAPGTSVKTNPNAIKTIQKNTIFTNVAETSDGGVYWEGIDEPLASGVTITSWKNKEWSSEDGEPCAHPNSRFCTPASQCPIIDAAWESPEGVPIEGIIFGGRRPAGVPLVYEALSWQHGVFVGAAMRSEATAAAEHKGKIIMHDPFAMRPFFGYNFGKYLAHWLSMAQHPAAKLPKIFHVNWFRKDKEGKFLWPGFGENSRVLEWMFNRIDGKASTKLTPIGYIPKEDALNLKGLGHINMMELFSISKEFWEKEVEDIEKYLEDQVNADLPCEIEREILALKQRISQM
  
Inhibitor
Name:
BDBM50214004
Synonyms:
CHEMBL243116 | N-(4-((1-(2-fluorobenzyl)-3-butyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)methyl)phenyl)-5-chloro-1,3-dimethyl-1H-pyrazole-4-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C28H29ClFN7O4S
Mol. Mass.:
614.091
SMILES:
CCCCn1c2nc(Cc3ccc(NS(=O)(=O)c4c(C)nn(C)c4Cl)cc3)[nH]c2c(=O)n(Cc2ccccc2F)c1=O
Structure:
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