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Target
Tyrosine-protein kinase Lyn
Ligand
BDBM50208746
Substrate
n/a
Meas. Tech.
ChEMBL_443314 (CHEMBL892515)
IC50
29±n/a nM
Citation
 Horio, T; Hamasaki, T; Inoue, T; Wakayama, T; Itou, S; Naito, H; Asaki, T; Hayase, H; Niwa, T Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives. Bioorg Med Chem Lett 17:2712-7 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase Lyn
Synonyms:
JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn
Type:
Protein
Mol. Mass.:
58575.92
Organism:
Homo sapiens (Human)
Description:
P07948
Residue:
512
Sequence:
MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
  
Inhibitor
Name:
BDBM50208746
Synonyms:
(4-((3-(dimethylamino)azetidin-1-yl)methyl)-3-(trifluoromethyl)phenyl)(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenylamino)methanol hydrochloride | CHEMBL536983
Type:
Small organic molecule
Emp. Form.:
C29H31F3N8O
Mol. Mass.:
564.6046
SMILES:
CN(C)C1CN(Cc2ccc(cc2C(F)(F)F)C(O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncnc3)c2)C1 |w:17.18|
Structure:
Search PDB for entries with ligand similarity: