Reaction Details Report a problem with these data
Target
Iron-starvation protein PigA
Ligand
BDBM52267
Substrate
n/a
Meas. Tech.
ChEMBL_444781 (CHEMBL895029)
Kd
72800±n/a nM
Citation
 Furci, LM; Lopes, P; Eakanunkul, S; Zhong, S; MacKerell, AD; Wilks, A Inhibition of the bacterial heme oxygenases from Pseudomonas aeruginosa and Neisseria meningitidis: novel antimicrobial targets. J Med Chem 50:3804-13 (2007) [PubMed]  Article 
Target
Name:
Iron-starvation protein PigA
Synonyms:
Heme oxygenase | Iron-starvation protein PigA
Type:
PROTEIN
Mol. Mass.:
21946.19
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_444781
Residue:
198
Sequence:
MDTLAPESTRQNLRSQRLNLLTNEPHQRLESLVKSKEPFASRDNFARFVAAQYLFQHDLEPLYRNEALARLFPGLASRARDDAARADLADLGHPVPEGDQSVREADLSLAEALGWLFVSEGSKLGAAFLFKKAAALELDENFGARHLAEPEGGRAQGWKSFVAILDGIELNEEEERLAAKGASDAFNRFGDLLERTFA
  
Inhibitor
Name:
BDBM52267
Synonyms:
6-amino-5-cyano-4-(4-hydroxy-3-methoxy-phenyl)-2-methyl-4H-pyran-3-carboxylic acid ethyl ester | 6-amino-5-cyano-4-(4-hydroxy-3-methoxyphenyl)-2-methyl-4H-pyran-3-carboxylic acid ethyl ester | MLS000530182 | SMR000135159 | cid_2831070 | ethyl 6-amino-5-cyano-4-(4-hydroxy-3-methoxyphenyl)-2-methyl-4H-pyran-3-carboxylate | ethyl 6-azanyl-5-cyano-4-(3-methoxy-4-oxidanyl-phenyl)-2-methyl-4H-pyran-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C17H18N2O5
Mol. Mass.:
330.3352
SMILES:
CCOC(=O)C1=C(C)OC(=N)C(C#N)C1c1ccc(O)c(OC)c1 |c:5|
Structure:
Search PDB for entries with ligand similarity: