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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50104694
Substrate
n/a
Meas. Tech.
ChEMBL_447846 (CHEMBL898096)
IC50
45000±n/a nM
Citation
 Jung, M; Lee, Y; Park, M; Kim, H; Kim, H; Lim, E; Tak, J; Sim, M; Lee, D; Park, N; Oh, WK; Hur, KY; Kang, ES; Lee, HC Design, synthesis, and discovery of stilbene derivatives based on lithospermic acid B as potent protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett 17:4481-6 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50104694
Synonyms:
(R)-4-hydroxy-5-(hydroxymethyl)-3-palmitoylfuran-2(5H)-one | (R)-5-Ethyl-3-hexadecanoyl-4-methyl-5H-furan-2-oneo | 3-Hexadecanoyl-4-hydroxy-5-hydroxymethyl-5H-furan-2-one | CHEMBL108441 | RK-682
Type:
Small organic molecule
Emp. Form.:
C21H36O5
Mol. Mass.:
368.5075
SMILES:
CCCCCCCCCCCCCCCC(=O)c1c(O)oc(CO)c1O
Structure:
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