Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase 1
Ligand
BDBM50220220
Substrate
n/a
Meas. Tech.
ChEMBL_449139 (CHEMBL899404)
IC50
20000±n/a nM
Citation
 Bhattarai, BR; Shrestha, S; Ham, SW; Kim, KR; Cheon, HG; Lee, KH; Cho, H 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett 17:5357-60 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase 1
Synonyms:
PTP1 | PTP1_YEAST | Protein-tyrosine phosphatase 1
Type:
PROTEIN
Mol. Mass.:
38875.77
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_217570
Residue:
335
Sequence:
MAAAPWYIRQRDTDLLGKFKFIQNQEDGRLREATNGTVNSRWSLGVSIEPRNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPLDNIVIVMVTPLVEYNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFPSDLKIEFVNVHKVKDYYTVTDIKLTPTDPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNSRGNPIIVHCSAGVGRTGTFIALDHLMHDTLDFKNITERSRHSDRATEEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHAAKYLNSLSVNQ
  
Inhibitor
Name:
BDBM50220220
Synonyms:
(5-benzyloxy-3-hydroxy-3',5'-bis-trifluoromethyl-biphenyl-4-yloxy)-acetic acid | CHEMBL238137
Type:
Small organic molecule
Emp. Form.:
C23H16F6O5
Mol. Mass.:
486.3606
SMILES:
OC(=O)COc1c(O)cc(cc1OCc1ccccc1)-c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: