Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50227661
Substrate
n/a
Meas. Tech.
ChEMBL_459972 (CHEMBL943100)
EC50
195±n/a nM
Citation
 Matthews, JM; Chen, X; Cryan, E; Hlasta, DJ; Rybczynski, PJ; Strauss, K; Tang, Y; Xu, JZ; Yang, M; Zhou, L; Demarest, KT Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists. Bioorg Med Chem Lett 17:6773-8 (2008) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
Nr1c1 | Nuclear receptor subfamily 1 group C member 1 | PPAR-alpha | PPARA_RAT | Peroxisome Proliferator-Activated Receptor alpha | Ppar | Ppara
Type:
PROTEIN
Mol. Mass.:
52374.28
Organism:
Rattus norvegicus
Description:
ChEMBL_834194
Residue:
468
Sequence:
MVDTESPICPLSPLEADDLESPLSEEFLQEMGNIQEISQSLGEESSGSFSFADYQYLGSCPGSEGSVITDTLSPASSPSSVSCPAVPTSTDESPGNALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLAYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDLKDSETADLKSLAKRIHEAYLKNFNMNKVKARVILAGKTSNNPPFVIHDMETLCMAEKTLVAKMVANGVENKEAEVRFFHCCQCMSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFTMLSSLMNKDGMLIAYGNGFITREFLKNLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNIGYIEKLQEGIVHVLKLHLQSNHPDDTFLFPKLLQKMVDLRQLVTEHAQLVQVIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50227661
Synonyms:
2-(2-(1-butyl-3-(4-(trifluoromethoxy)phenyl)ureido)-2,3-dihydro-1H-inden-5-ylthio)-2-methylpropanoic acid | CHEMBL399089
Type:
Small organic molecule
Emp. Form.:
C25H29F3N2O4S
Mol. Mass.:
510.569
SMILES:
CCCCN(C1Cc2ccc(SC(C)(C)C(O)=O)cc2C1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |w:5.4|
Structure:
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