Reaction Details Report a problem with these data
Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM50235113
Substrate
n/a
Meas. Tech.
ChEMBL_462693 (CHEMBL929667)
IC50
182±n/a nM
Citation
Macdonald, D; Brideau, C; Chan, CC; Falgueyret, JP; Frenette, R; Guay, J; Hutchinson, JH; Perrier, H; Prasit, P; Riendeau, D; Tagari, P; Thérien, M; Young, RN; Girard, Y Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. Bioorg Med Chem Lett 18:2023-7 (2008) [PubMed] Article
More Info.:
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
Inhibitor
Name:
BDBM50235113
Synonyms:
CHEMBL258215 | methyl 2-(4-(2-(4-(quinolin-2-ylmethoxy)phenyl)bicyclo[2.2.1]heptan-2-yl)phenoxy)acetate
Type:
Small organic molecule
Emp. Form.:
C32H31NO4
Mol. Mass.:
493.5928
SMILES:
COC(=O)COc1ccc(cc1)C1(CC2CCC1C2)c1ccc(OCc2ccc3ccccc3n2)cc1 |w:14.15,17.17,12.12,THB:19:12:16.15:18,TEB:9:12:16.15:18|