Reaction Details Report a problem with these data
Target
Adenosylhomocysteinase
Ligand
BDBM50373101
Substrate
n/a
Meas. Tech.
ChEMBL_466721 (CHEMBL937442)
IC50
1980±n/a nM
Citation
 Ando, T; Iwata, M; Zulfiqar, F; Miyamoto, T; Nakanishi, M; Kitade, Y Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. Bioorg Med Chem 16:3809-15 (2008) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
AdoHcyase | PfSAHH | S-adenosyl-L-homocysteine hydrolase | SAHH_PLAF7
Type:
PROTEIN
Mol. Mass.:
53833.80
Organism:
Plasmodium falciparum 3D7
Description:
ChEMBL_196715
Residue:
479
Sequence:
MVENKSKVKDISLAPFGKMQMEISENEMPGLMRIREEYGKDQPLKNAKITGCLHMTVECALLIETLQKLGAQIRWCSCNIYSTADYAAAAVSTLENVTVFAWKNETLEEYWWCVESALTWGDGDDNGPDMIVDDGGDATLLVHKGVEYEKLYEEKNILPDPEKAKNEEERCFLTLLKNSILKNPKKWTNIAKKIIGVSEETTTGVLRLKKMDKQNELLFTAINVNDAVTKQKYDNVYGCRHSLPDGLMRATDFLISGKIVVICGYGDVGKGCASSMKGLGARVYITEIDPICAIQAVMEGFNVVTLDEIVDKGDFFITCTGNVDVIKLEHLLKMKNNAVVGNIGHFDDEIQVNELFNYKGIHIENVKPQVDRITLPNGNKIIVLARGRLLNLGCATGHPAFVMSFSFCNQTFAQLDLWQNKDTNKYENKVYLLPKHLDEKVALYHLKKLNASLTELDDNQCQFLGVNKSGPFKSNEYRY
  
Inhibitor
Name:
BDBM50373101
Synonyms:
CHEMBL405186
Type:
Small organic molecule
Emp. Form.:
C11H14FN5O3
Mol. Mass.:
283.259
SMILES:
Nc1nc(F)nc2n(cnc12)[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O
Structure:
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