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Target
Histone deacetylase 6
Ligand
BDBM50232034
Substrate
n/a
Meas. Tech.
ChEMBL_468839 (CHEMBL947926)
IC50
>50000±n/a nM
Citation
 Methot, JL; Chakravarty, PK; Chenard, M; Close, J; Cruz, JC; Dahlberg, WK; Fleming, J; Hamblett, CL; Hamill, JE; Harrington, P; Harsch, A; Heidebrecht, R; Hughes, B; Jung, J; Kenific, CM; Kral, AM; Meinke, PT; Middleton, RE; Ozerova, N; Sloman, DL; Stanton, MG; Szewczak, AA; Tyagarajan, S; Witter, DJ; Secrist, JP; Miller, TA Exploration of the internal cavity of histone deacetylase (HDAC) with selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett 18:973-8 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 6
Synonyms:
Cereblon/Histone deacetylase 6 | HD6 | HDAC6 | HDAC6_HUMAN | Histone deacetylase 6 (HDAC6) | Human HDAC6 | KIAA0901 | ORF Names:JM21
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
131381.51
Organism:
Homo sapiens (Human)
Description:
Q9UBN7
Residue:
1215
Sequence:
MTSTGQDSTTTRQRRSRQNPQSPPQDSSVTSKRNIKKGAVPRSIPNLAEVKKKGKMKKLGQAMEEDLIVGLQGMDLNLEAEALAGTGLVLDEQLNEFHCLWDDSFPEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELMLVHSLEYIDLMETTQYMNEGELRVLADTYDSVYLHPNSYSCACLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRIRRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYTINVPWNQVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQGDPKGEMAATPAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLGDPCPMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPPVLPILTWPVLQSRTGLVYDQNMMNHCNLWDSHHPEVPQRILRIMCRLEELGLAGRCLTLTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESSNFDSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSVAVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEGASSQIGRAAGTGFTVNVAWNGPRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDAARGDPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLGDPPPLLTLPRPPLSGALASITETIQVHRRYWRSLRVMKVEDREGPSSSKLVTKKAPQPAKPRLAERMTTREKKVLEAGMGKVTSASFGEESTPGQTNSETAVVALTQDQPSEAATGGATLAQTISEAAIGGAMLGQTTSEEAVGGATPDQTTSEETVGGAILDQTTSEDAVGGATLGQTTSEEAVGGATLAQTTSEAAMEGATLDQTTSEEAPGGTELIQTPLASSTDHQTPPTSPVQGTTPQISPSTLIGSLRTLELGSESQGASESQAPGEENLLGEAAGGQDMADSMLMQGSRGLTDQAIFYAVTPLPWCPHLVAVCPIPAAGLDVTQPCGDCGTIQENWVCLSCYQVYCGRYINGHMLQHHGNSGHPLVLSYIDLSAWCYYCQAYVHHQALLDVKNIAHQNKFGEDMPHPH
  
Inhibitor
Name:
BDBM50232034
Synonyms:
CHEMBL256440 | N-(2-amino-5-(thiophen-2-yl)phenyl)nicotinamide
Type:
Small organic molecule
Emp. Form.:
C16H13N3OS
Mol. Mass.:
295.359
SMILES:
Nc1ccc(cc1NC(=O)c1cccnc1)-c1cccs1
Structure:
Search PDB for entries with ligand similarity: