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Target
Mitogen-activated protein kinase 1
Ligand
BDBM50374681
Substrate
n/a
Meas. Tech.
ChEMBL_469834 (CHEMBL949019)
IC50
>3000±n/a nM
Citation
 Goldberg, DR; Choi, Y; Cogan, D; Corson, M; DeLeon, R; Gao, A; Gruenbaum, L; Hao, MH; Joseph, D; Kashem, MA; Miller, C; Moss, N; Netherton, MR; Pargellis, CP; Pelletier, J; Sellati, R; Skow, D; Torcellini, C; Tseng, YC; Wang, J; Wasti, R; Werneburg, B; Wu, JP; Xiong, Z Pyrazinoindolone inhibitors of MAPKAP-K2. Bioorg Med Chem Lett 18:938-41 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM50374681
Synonyms:
CHEMBL257834
Type:
Small organic molecule
Emp. Form.:
C29H36N6O3S
Mol. Mass.:
548.7
SMILES:
CC(C)(C)CN1CCC(CC1)NC(=O)c1csc(NC(=O)c2ccc3cc4C(=O)NCC5(CCC5)n4c3c2)n1
Structure:
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