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Target
RmtA
Ligand
BDBM50376153
Substrate
n/a
Meas. Tech.
ChEMBL_475539 (CHEMBL925748)
IC50
161600±n/a nM
Citation
 Mai, A; Cheng, D; Bedford, MT; Valente, S; Nebbioso, A; Perrone, A; Brosch, G; Sbardella, G; De Bellis, F; Miceli, M; Altucci, L epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem 51:2279-90 (2008) [PubMed]  Article 
Target
Name:
RmtA
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
39351.26
Organism:
Emericella nidulans
Description:
ChEMBL_475539
Residue:
345
Sequence:
MSEIENSTITSSADRMVGMDHAEVRYFTSYDHHGIHEEMLKDDVRTRSYRDSIYQNRHIFKDKVVLDVGCGTGILSMFAAKAGAKHVIGVDMSSIIEKAREIVAVNGLADKITLLQGKMEEVQLPFPSVDIIISEWMGYFLLYESMLDTVLYAQDRYLVPGGKIFPDKATMYLAGIEDGEYKDDKIGFWDNVYGFDYSPMKEIALTEPLVDTVELKALVTDPCPIITFDLYTVTKEDLAFEVPYSLPVKRSDFVHAVIAWFDIEFGACHKPINFSTGPHAKYTHWKQTVFYLRDVLTVEEEESISGVLSNRPNDKNKRDLDINLTYKLETQDQTRFAEGGCFYRM
  
Inhibitor
Name:
BDBM50376153
Synonyms:
CHEMBL259459
Type:
Small organic molecule
Emp. Form.:
C20H17Br2NO3
Mol. Mass.:
479.162
SMILES:
CN1C\C(=C/c2ccc(O)c(Br)c2)C(=O)\C(C1)=C\c1ccc(O)c(Br)c1
Structure:
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